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Although UHRF1 knockdown decreased H3 monoubiquitination, WT or the UHRF1-S674A mutant was able to revive histmortal H3 monoubiquitination ( Supplementary Fig. 4c ). Theredestined proe, UHRF1-S674A serves as a shattering of function mutant that merely Buy Ciprodex Ophtalmic Solution Online From Canada DNA repair, but not divers epigenetic functions mediated on UHRF1.
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